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Trusted by 1000s of physicians, Zeotone® Plus is one of the most potent stand-alone options for treating osteoarthritis. The product has a Sneha amsha which is anti-degenerative and herbal extracts of several anti-inflammatory ingredients.


Zeotone®Plus is clinically validated by a randomized double-blind study conducted by a WHO approved CRO which showed tremendous results. Zeotone® Plus stand-alone brought about a functional improvement of more than 38% in less than 2 months and a pain relief of over 70% which is unprecedented in the market.

Product Indications

    • Osteo-arthritis / Osteo-arthrosis
    • Tennis elbow & Golfer’s elbow
    • Inflammatory arthritis after the stage of active inflammation
    • Ligament injury

Effective Dosage

The effective dosage of Zetone®Plus would be 2 capsules twice daily before having food.

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Product Benefits And Features

    • Trusted by thousands of Ayurvedic physicians across India, Zeotone®Plus is a highly effective medication in managing Osteo-Arthritis. It is developed by the combination of an effective anti-degenerative oil & powerful anti-inflammatory extracts, ensuring complete care for osteoarthritis.
    • Zeotone Plus soft gelatin capsules is a potent anti-inflammatory medicine that helps reduce pain and stiffness in joints in patients.
    • It is a unique combination of anti-inflammatory and anti-degenerative ingredients which helps to completely treat osteoarthritis.
    • It contains Gandha Taila, Cissus quadrangularis and other anti-degenerative ingredients that help stop and reverse Tissue & Cartilage damage.
    • It contains Shallaki and Guggulu, which are highly potent anti-inflammatory herbs that help bring rapid relief to pain in joints & also helps in stopping the process of degeneration which is caused due to inflammation in joints.
    • Zeotone Plus prevents degeneration of cartilages and promotes its growth.

Ingredients & Composition

Ayurvedic understanding of the product

The most common cause for knee / hip pain is Primary osteo-arthritis (or) osteo-arthrosis which is primarily due to degenerative changes seen in the cartilage & the articular cartilages. This phenomenon in Ayurveda is described as “SandhiGata Vata” which is considered to be a Kevala vata vikara.

बाह्यभ्यन्तरतः स्नेहो अस्थिमज्जागतम् जयेत् ।

Bahya abhyantaratah sneho asthimajjagatam jayet.

It is said that snehana(both bahya & abhyantara) is the mode of treatment for when Prakupita vata has it’s sthana samshraya in Asthi, majja & sandhi.

Guggulu & Shallaki with it’s Ushna & Teekshna gunas and Katu rasa is an ideal drug which is commonly used as a rasayana in vatavyadhi.

With these insights & AVN’s experience with the management of Osteo-arthritis, Zeotone Plus was formulated. It contains Gandha tailam (which is Asthi sthairyakrit) a proprietary Ayurvedic thailam (Sesame oil processed with vatahara dravyas like dasamoola) & Extracts of Guggulu, Shallaki & Haridra. It also contains Shanka Bhasmam which acts as a source of calcium & also reduces the effect of guggulu & sallaki in the GI preventing side-effects like acidity.

Research work

Zeotone Plus is made up of many potent herbs like Cedrus Deodara, Boswellia Serrata, Commiphora Wightii, Trigonella Foenum-graecum amongst others. This makes it highly effective in the treatment of osteoarthritis. Most of the herbs in this formulation are mentioned in Ayurveda for the management of Asthi-majja gata vikaras, predominantly vataja vikaras.

Validating the efficacy of Zeotone Plus

S.No Ingredients Target enzymes/ receptors Purpose
1 Boswellia serrata 5-Lipoxigenase, human leukocyte elastase enzyme, MMP-3, 10 and 12, TNF-alfa, IL-1β, IL-6 NF-κB, Supports joint flexibility Acts on synovial fluid Reduces swelling Protects cartilage Rejuvenates chondrocytes and cartilage
2 Curcuma longa IL-1β, IL-6, IL-8 COX-2, 5-LOX, NF-kB, TNF-α, MMPs 1, 3, 9 and 13, phospholipase A2 Fights reactive oxygen species Acts in synergy with boswellia Protects chrondrocytes and cartilage
3 Commiphora wightii NF-κB, STAT-3, COX-1 and COX-2 Reduces pain and stiffness
4 Cissus quadrangularis MMP-3, MMP-9, MMP-12, MMP-13, MMP-15,(PGE2), L-1β, IL-18, TNF-α, NF-kB, P38-MAPK. Improves bone health, reduces joint swelling, protect cartilage, improves mobility
5 WIthania somnifera Smurf2, NF-κB, TNF-alfa Protects and rejuvenates cartilage, immunomodulatory properties
6 Trigonella foenum-graecum IL-1α, IL-1β, IL-2, IL-6 and TNF-α, COX, LOX Antioxidant and reduces swellings
7 Commiphora myrraha IL-1β, IL-2, IL-10, IL-12, TNFα, INFγ Analgesic activity, eases joint pain
8 Asparagus racemosu TNF-α Reduces inflammation
9 Sesamum indicum oil IL-1α, IL-6 and TNF-alfa Reduces swelling
10 Gmelina arborea Analgesic and antiinflammatory activities
11 Aegle marmelos IL-2, IL-1β, MIP1-α, IL-6, COX-1 and COX-2 Reduces swelling
12 Clerodendrum phlomidis TNF, IL-1 and IL-6 Reduces inflammation in joints
13 Hordeum vulgare SOD, GPx,COX and LOX Fights oxidative damage and reduces swelling
14 Vigna unguiculata IL-8, TNF-α, VCAM-1, NF-κB, VCAM-1 Reduces swelling and pain
15 Glycyrrhiza glabra COX-2 and TXA2 Reduces swelling in joint
16 Herbs of gandha tailam reported for IL-1β, IL-2, Improves bone mass and strength, healing effects on
17 Gandha tailam Herbs of gandha tailam reported for IL-1β, IL-2, IL-10, IL-12, TNFα, INFγ, COX-2 and TXA2, 5-Lipoxigenase, human leukocyte elastase enzyme, MMP-3, 10 and 12, TNF-alfa, IL-1β, IL-6 NF-κB, Improves bone mass and strength, healing effects on the ligament and knee & joint injuries, reduces bone degeneration


Here Our Doctor Stories


01 Is the product clinically validated?

Yes. The product is clinically validated by a randomized double-blind study conducted by a WHO approved CRO which showed tremendous results.

02 Can the product be used in auto-immune arthritis?

03 Why is the product in the form of a soft gel capsule?

04 How long does the product take to show effects?

05 How long should the product be consumed ?

06 Are there any side effects?

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